Proper seeding depth control is essential to optimize row-crop planter performance, and adjustment of planter settings to within field spatial variability is required to maximize crop yield potential. The objectives of this study were to characterize planting depth response to varying soil conditions within fields, and to discuss implementation of active seeding depth technologies in Southeastern US. This study was conducted in 2014 and 2015 in central Alabama for non-irrigated maize (Zea mays L) and cotton (Gossypium hirsutum L). Planting was performed using a 6-row John Deere Max Emerge Plus planter equipped with heavy duty downforce springs. Three seeding depths and three downforce settings were selected for both crops, and the experiment was conducted in two fields exhibiting typical Coastal Plain features but characterized by different soil properties and terrain attributes. Soil electrical-conductivity and soil water content were used to measure within field spatial variability, and actual planting depth was characterized after emergence. Results demonstrated that actual planting depth was significantly affected by within field spatial variability, and actual planting depth response to field spatial variability was more accentuated during corn versus cotton planting. Soil electrical conductivity provided sufficient description of in-field variability to explain site-specific planting depth response in 4 out of 5 field trials. Soil water content was not a significant predictor of planting depth response to in-field spatial variability.