The objective of this study was to evaluate the effects of increasing levels of crude protein (CP) substitution of the concentrate by CP of crambe meal (CM) (0, 25, 50 and 75% dry matter basis) on consumption of nutrients. Four rumen fistulated and castrated sheep (18 months old on average and initial body weight of 50 kg) were used distributed in a 4 x 4 Latin square design with 4 treatments and 4 experimental periods (repetitions). Diets were balanced to meet requirements for minimum gains of 50 grams/animal/day with approximately 14% CP and 70% total digestible nutrients (TDN). The roughage to concentrate ratio was 50:50. Animals had free access to food, water, and mineral mixture. Each experimental period contained 14 days, seven days for the adaptation of the animals to the diet and the experimental conditions and seven days for sample collection. Foods supplied and leftovers were quantified daily to measure the individual intake of dry matter (DM), crude protein (CP), ethereal extract (EE), neutral detergent fiber corrected for ashes and protein (NDFap), non-fibrous carbohydrate (NFC), and total carbohydrate. The intake was expressed in kilograms per day (kg/day), grams per kilogram of body weight (g/kg BW), and grams per kg of metabolic weight (g/kg BW0.75). The results were submitted to analysis of variance and regression study at 5% of significance. There was a linear increasing effect (P < 0.05) on EE consumption (kg/day), which can be mainly attributed to differences in diets formulation. In addition, a linear decreasing effect (P < 0.05) was observed for NFC intake, as well as DM, OM, EE, NDFap, NFCap, and TDN (P < 0.05). However, no effect was observed for digestibility of CP (P > 0.05). Thus, it can be concluded that crambe meal can be used to feed sheep without compromising feed intake of the animals.