Nitrogen is one of the elements that are essential to maximizing agricultural productivity and economic returns for farmers. Its management is difficult because this element is very dynamic and mobile, characteristics that can contribute to significant losses via atmospheric, surface and/or leaching pathways. The magnitude of these losses can be affected by site-specific physical and chemical factors. These physical and chemical factors can vary significantly across the landscape, adding to the complexity of managing nitrogen. A new tool that can be used to quickly integrate spatial variabilities and contribute to the assessment of risky landscape-management combinations has recently been developed: the NLEAP-GIS tool can facilitate the download of U.S. GIS soil databases as well as climate databases that have been collected by weather stations across the U.S., and quickly format these databases to conduct evaluations across a given site-specific field.  Users will need to set up the management data to be evaluated. An NLEAP-GIS nitrogen management database is being developed to help integrate soil, weather and management databases. Results from studies across several U.S. regions using GIS, ranging from corn-soybean rotations in the North Atlantic region, to manure applications in the Midwest, to corn and vegetable production in the irrigated western United States, show that NLEAP-GIS is a useful tool for assessing the effects of nitrogen inputs across risky landscape-management combinations and can potentially be used to assess the effects of nitrogen management on nitrogen use efficiencies across the USA.