Spatial variability for crop productivity in the southeastern US Coastal Plain is often due to differences in soil water holding capacity. An experiment was conducted to investigate the use of soil EC as an aid in the site-specific application of sidedress N to cotton. Treatments in the study consisted of three N rates (0, 34, and 112 kg N ha^-1). Each treatment was replicated four times in plots that were 4 m wide (four cotton rows) and 350 m long. Soil EC was measured with a Veris 3100 system before cotton planting. Soil EC ranged in the field from less than 1 milliSiemen m^-1 to greater than 8 milliSiemens m^-1. All nitrogen was applied at planting, and NDVI was measured with a tractor-mounted Crop Circle ACS 210 at 28, 37, 42, and 50 days after planting. Cotton yield was measured at the end of the with a yield monitor. At the earliest sampling time, there was little difference between the N rates at any soil EC level. Differences among the N rates for NDVI at 42 and 50 days after planting depended on soil EC, with greatest differences occurring at EC levels between 2 and 5 milliSiemen m^-1. Similarly, the yield response to N was dependent on soil EC level with greatest differences among the N rates between 2 and 5 milliSiemen m^-1.